Fionna Derm Lightening cream

Product



Fionna Derm Ltd. provides only highly innovative solutions to the market which are based on the modern scientific research and are unique. The company has been established after the successful partnership between Micar21 Ltd. drug design team and Fionna Cosmetics Ltd. producer. Fionna Derm develops both new active substances and cosmetics formulations. For our cosmetics we mainly use compounds that have been recently developed. All of our products are subject of clinical trials, for safety and efficacy, before we submit them to the market.

Melasma (pigmentation) is well known cosmetic issue and is mainly due to the abnormal melanin production, which in turn is produced by the Tyrosinase and Tyrosinase-related protein 1 (TYR and TYRP1) enzymes. Consequently, 90% of the cosmetics products on the marked target and suppress the melanin production via these proteins using active substances such as Kojic acid. We use such an approach too blocking the TYR and TYRP1 by the combination of Deoxyarbutin and 4-Butylresorcinol. However, our secret is based on the recently published new scientific data which clearly indicate that the reason of Melasma is not only related to the high level of the TYR and TYRP1 but also other enzymes play significant role. Surprisingly, up to the 40% of the people do not have any significant increase of the above mentioned proteins which explains why provided cosmetic solutions work for one person but not for other. In contrast, it has been shown that other proteins and pathways are equally involved such as the WIF1 (Wnt pathway) and PPARα receptor (lipid metabolism). In fact, the level of WIF1 was increased as much as those of the Tyrosinase’s (please see Tables in the pined post). Thus, our Fiona Derm Lightening cream contains also active substances that regulate both the WIF1 and PPARα proteins expression in the aim to normalize the levels of the most enzymes involved in the Melasma development, i.e. TYR, TYRP1, WIF1 and PPARα. It is evident that our product has four ways of action, as such also all other from the same brand, and correspondently our logo is named “4 way action”. This is a worldwide innovation that guaranties the significant advantage of Fionna Derm lightening cream, which in particular will initiate a new generation of anti-Melasma cosmetics. In support to above data we performed clinical trials for safety and efficacy. Results showed significant improvements after just the 15th day and almost completely face clearing after only 4-6 weeks, i.e. after the skin cell regeneration. These results will be submitted for a scientific publication soon. Another significant advantage of the suggested lightening cream is that it prevents formation of new dark spots. We highly recommend using Fiona Derm Lightening cream in a combination with some piling agents to speed up the clearing process. The cream should be used after the face was cleaned. Keep the cream in a cold and dark environment.

In support to above data we performed clinical trials for safety and efficacy. Results showed significant improvements after just the 15th day and almost completely face clearing after only 4-6 weeks, i.e. after the skin cell regeneration. These results will be submitted for a scientific publication soon. Another significant advantage of the suggested lightening cream is that it prevents formation of new dark spots. We highly recommend using Fiona Derm Lightening cream in a combination with some piling agents to speed up the clearing process. The cream should be used after the face was cleaned. Keep the cream in a cold and dark environment.



Lightening effect observed on the 1st (right) and day 15 (left) using Fionna Derm Lightening cream.



The regulation of Wnt pathway by Fionna Derm Lightening cream



Observed increase of the levels of TYR and TYRP1 enzymes in seven people (left) and the total increase of the TYRP1 and WIF1 genes in a group of 18 women. Journal of Investigative Dermatology (2011) 131, 1692–1700;

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